Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors.

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Foley LH, Palermo R, Dunten P, Wang P

Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors.

Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72.

PubMed ID

11327602 [ View in PubMed

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Abstract

The 5,5-disubstitutedpyrimidine-2,4,6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione	Stromelysin-1	IC 50 (nM)	2000	N/A	N/A	Details