Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.
Article Details
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Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G
Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.
Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8.
- PubMed ID
- 14592488 [ View in PubMed]
- Abstract
Heat shock protein 90 (Hsp90) is a molecular chaperone necessary for maintaining oncogenic transformation. There is substantial interest in developing novel agents that bind to the N-terminal of the chaperone. Here we report the synthesis and characterization of two fluorescent Hsp90 inhibitors and probe their use in an Hsp90 fluorescent polarization assay.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Heat shock protein HSP 90-alpha EC 50 (nM) 3200 N/A N/A Details