Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
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Lau CK, Bayly CI, Gauthier JY, Li CS, Therien M, Asante-Appiah E, Cromlish W, Boie Y, Forghani F, Desmarais S, Wang Q, Skorey K, Waddleton D, Payette P, Ramachandran C, Kennedy BP, Scapin G
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Bioorg Med Chem Lett. 2004 Feb 23;14(4):1043-8.
- PubMed ID
- 15013020 [ View in PubMed]
- Abstract
A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors. Molecular modeling on the X-ray crystal structure of the lead structure led to the design of potent PTP-1B inhibitors that show moderate selectivity against TC-PTP, a very closely related protein tyrosine phosphatase.
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