Inhibitors selective for HDAC6 in enzymes and cells.
Article Details
- CitationCopy to clipboard
Gupta PK, Reid RC, Liu L, Lucke AJ, Broomfield SA, Andrews MR, Sweet MJ, Fairlie DP
Inhibitors selective for HDAC6 in enzymes and cells.
Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70. doi: 10.1016/j.bmcl.2010.09.100. Epub 2010 Oct 12.
- PubMed ID
- 20947351 [ View in PubMed]
- Abstract
Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Vorinostat Histone deacetylase 1 IC 50 (nM) 76 N/A N/A Details Vorinostat Histone deacetylase 6 IC 50 (nM) 85 N/A N/A Details