A new class of selective and potent inhibitors of neuronal nitric oxide synthase.

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Lowe JA 3rd, Qian W, Volkmann RA, Heck S, Nowakowski J, Nelson R, Nolan C, Liston D, Ward K, Zorn S, Johnson C, Vanase M, Faraci WS, Verdries KA, Baxter J, Doran S, Sanders M, Ashton M, Whittle P, Stefaniak M

A new class of selective and potent inhibitors of neuronal nitric oxide synthase.

Bioorg Med Chem Lett. 1999 Sep 6;9(17):2569-72.

PubMed ID

10498210 [ View in PubMed

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Abstract

The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this series shows potent and selective inhibition of the human nNOS isoform, with pharmacokinetics sufficient to provide in vivo inhibition of nNOS activity.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
7-Nitroindazole	Nitric oxide synthase, endothelial	IC 50 (nM)	1890	N/A	N/A	Details