Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.
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Perola E, Cellai L, Brufani M
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.
Bioorg Med Chem Lett. 1998 Mar 17;8(6):575-80.
- PubMed ID
- 9871563 [ View in PubMed]
- Abstract
A series of N-[omega-N'-(adamant-1'-yl)aminoalkyl]-2-(4'- dimethylaminophenyl)acetamides were synthesized and tested as acetylcholinesterase inhibitors. A significant selectivity toward acetylcholinesterases from various natural sources, mainly differing in their quaternary structure and solubility, was pointed out. The interest of this kind of molecules as potential therapeutic agents for Alzheimer's disease is discussed.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Donepezil Acetylcholinesterase IC 50 (nM) 8 N/A N/A Details Donepezil Acetylcholinesterase IC 50 (nM) 12 N/A N/A Details Donepezil Acetylcholinesterase IC 50 (nM) 17 N/A N/A Details Physostigmine Acetylcholinesterase IC 50 (nM) 47 N/A N/A Details Physostigmine Acetylcholinesterase IC 50 (nM) 46 N/A N/A Details