Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands.
Article Details
- CitationCopy to clipboard
Zajdel P, Subra G, Bojarski AJ, Duszynska B, Pawlowski M, Martinez J
Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands.
Bioorg Med Chem Lett. 2006 Jul 1;16(13):3406-10. Epub 2006 May 3.
- PubMed ID
- 16677812 [ View in PubMed]
- Abstract
A library consisting of 60 arylpiperazines modified with N-acylated amino acids was prepared on BAL linker SynPhasetrade mark Lanterns and evaluated in vitro for 5-HT(1A) receptor affinity. Biological screening, followed by a simple Fujita-Ban analysis, enabled the description of structure-activity relationships and allowed the selection of some potent, high-affinity ligands for in vivo pharmacological investigations.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Buspirone 5-hydroxytryptamine receptor 1A Ki (nM) 17 N/A N/A Details