4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.
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Patane MA, Scott AL, Broten TP, Chang RS, Ransom RW, DiSalvo J, Forray C, Bock MG
4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.
J Med Chem. 1998 Apr 9;41(8):1205-8.
- PubMed ID
- 9548811 [ View in PubMed]
- Abstract
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Prazosin Alpha-1A adrenergic receptor Ki (nM) 0.39 N/A N/A Details Prazosin Alpha-1B adrenergic receptor Ki (nM) 0.21 N/A N/A Details Prazosin Alpha-1D adrenergic receptor Ki (nM) 0.2 N/A N/A Details Terazosin Alpha-1A adrenergic receptor Ki (nM) 4.2 N/A N/A Details Terazosin Alpha-1B adrenergic receptor Ki (nM) 1.2 N/A N/A Details Terazosin Alpha-1D adrenergic receptor Ki (nM) 2 N/A N/A Details