Pyrrolidinoindoline alkaloids from Selaginella moellendorfii.

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Wang YH, Long CL, Yang FM, Wang X, Sun QY, Wang HS, Shi YN, Tang GH

Pyrrolidinoindoline alkaloids from Selaginella moellendorfii.

J Nat Prod. 2009 Jun;72(6):1151-4. doi: 10.1021/np9001515.

PubMed ID

19422203 [ View in PubMed

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Abstract

Eight new pyrrolidinoindoline alkaloids (1-8) were isolated from the whole plant of Selaginella moellendorfii. Their structures were determined by mass spectrometry, 1D and 2D NMR spectroscopy, and chemical interconversions. These alkaloids have a 3-carboxybut-2-enyl group at C-3a and two methyl groups at N-8. The possible biogenetic route from selaginellic acid (1) to neoselaginellic acid (6) was postulated and chemically mimicked. Tautomerization between 6 and 6a was observed. Selected compounds were evaluated for antibacterial, cytotoxic, and acetylcholinesterase inhibitory activities.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Tacrine	Acetylcholinesterase	IC 50 (nM)	200	N/A	N/A	Details