Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens.

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Miller CP, Collini MD, Tran BD, Harris HA, Kharode YP, Marzolf JT, Moran RA, Henderson RA, Bender RH, Unwalla RJ, Greenberger LM, Yardley JP, Abou-Gharbia MA, Lyttle CR, Komm BS

Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens.

J Med Chem. 2001 May 24;44(11):1654-7.

PubMed ID

11356100 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Diethylstilbestrol	Estrogen receptor alpha	IC 50 (nM)	3	N/A	N/A	Details
Diethylstilbestrol	Estrogen receptor beta	IC 50 (nM)	4	N/A	N/A	Details
Raloxifene	Estrogen receptor alpha	IC 50 (nM)	4	N/A	N/A	Details
Raloxifene	Estrogen receptor beta	IC 50 (nM)	43	N/A	N/A	Details