Calcium channel antagonist effects of spironolactone, an aldosterone antagonist.
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Mironneau J
Calcium channel antagonist effects of spironolactone, an aldosterone antagonist.
Am J Cardiol. 1990 Jun 19;65(23):7K-8K; discussion 3K. doi: 10.1016/0002-9149(90)91267-a.
- PubMed ID
- 2162139 [ View in PubMed]
- Abstract
The effect of spironolactone on the contractility of vascular smooth muscle cells and on calcium channel currents of isolated cells was investigated using the patch-clamp method. Concentrations of 10 and 60 microM of spironolactone resulted in 50 and 100% inhibition, respectively, of isometric contractions. Whereas fast calcium channel current was essentially unaffected by spironolactone, slow calcium channel current was inhibited 50% by 5 to 7 microM concentrations of the drug. These results suggest that spironolactone acts on slow calcium channels in a manner similar to that of calcium blockers.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Spironolactone Voltage-dependent L-type calcium channel (Protein Group) Protein group Humans UnknownInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareNorepinephrineSpironolactone The therapeutic efficacy of Norepinephrine can be decreased when used in combination with Spironolactone.