Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation.
Article Details
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Serio AW, Keepers T, Andrews L, Krause KM
Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation.
EcoSal Plus. 2018 Nov;8(1). doi: 10.1128/ecosalplus.ESP-0002-2018.
- PubMed ID
- 30447062 [ View in PubMed]
- Abstract
Aminoglycosides are cidal inhibitors of bacterial protein synthesis that have been utilized for the treatment of serious bacterial infections for almost 80 years. There have been approximately 15 members of this class approved worldwide for the treatment of a variety of infections, many serious and life threatening. While aminoglycoside use declined due to the introduction of other antibiotic classes such as cephalosporins, fluoroquinolones, and carbapenems, there has been a resurgence of interest in the class as multidrug-resistant pathogens have spread globally. Furthermore, aminoglycosides are recommended as part of combination therapy for empiric treatment of certain difficult-to-treat infections. The development of semisynthetic aminoglycosides designed to overcome common aminoglycoside resistance mechanisms, and the shift to once-daily dosing, has spurred renewed interest in the class. Plazomicin is the first new aminoglycoside to be approved by the FDA in nearly 40 years, marking the successful start of a new campaign to rejuvenate the class.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Gentamicin Bacterial outer membrane Group Bacteria YesIncorporation into and destabilizationDetails Gentamicin Cytoplasmic membrane Group Bacteria YesIncorporation into and destabilizationDetails Streptomycin Bacterial outer membrane Group Bacteria YesIncorporation into and destabilizationDetails Streptomycin Cytoplasmic membrane Group Bacteria YesIncorporation into and destabilizationDetails Tobramycin 16S ribosomal RNA Nucleotide Enteric bacteria and other eubacteria YesInhibitorDetails Tobramycin Bacterial outer membrane Group Bacteria YesIncorporation into and destabilizationDetails Tobramycin Cytoplasmic membrane Group Bacteria YesIncorporation into and destabilizationDetails