Adenosine Metabolism: Emerging Concepts for Cancer Therapy.
Article Details
- CitationCopy to clipboard
Boison D, Yegutkin GG
Adenosine Metabolism: Emerging Concepts for Cancer Therapy.
Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007.
- PubMed ID
- 31821783 [ View in PubMed]
- Abstract
Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor escape from the host immune system. Major gaps in knowledge that impede the development of effective adenosine-based therapeutics include: (1) lack of consideration of redundant pathways controlling ATP and adenosine levels; (2) lack of distinction between receptor-dependent and -independent effects of adenosine, and (3) focus on extracellular adenosine without consideration of intracellular metabolism and compartmentalization. In light of current clinical trials, we provide an overview of adenosine metabolism and point out the need for a more careful evaluation of the entire purinome in emerging cancer therapies.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Adenosine Adenosine deaminase Protein Humans UnknownSubstrateDetails Adenosine Adenosine kinase Protein Humans UnknownSubstrateDetails Adenosine Adenylate kinase isoenzyme 1 Protein Humans UnknownSubstrateDetails Adenosine Nucleoside diphosphate kinase A Protein Humans UnknownSubstrateDetails Adenosine Nucleoside diphosphate kinase B Protein Humans UnknownSubstrateDetails Adenosine Purine nucleoside phosphorylase Protein Humans UnknownSubstrateDetails - Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Adenosine Equilibrative nucleoside transporter 1 Protein Humans UnknownSubstrateDetails Adenosine Equilibrative nucleoside transporter 2 Protein Humans UnknownSubstrateDetails Adenosine Equilibrative nucleoside transporter 3 Protein Humans UnknownSubstrateDetails Adenosine Equilibrative nucleoside transporter 4 Protein Humans UnknownSubstrateDetails Adenosine Gap junction alpha-1 protein Protein Humans UnknownSubstrateDetails Adenosine Sodium/nucleoside cotransporter 1 Protein Humans UnknownSubstrateDetails Adenosine Sodium/nucleoside cotransporter 2 Protein Humans UnknownSubstrateDetails - Drug Reactions
Reaction Details Details
