Therapeutic antibodies: their mechanisms of action and the pathological findings they induce in toxicity studies.

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Suzuki M, Kato C, Kato A

Therapeutic antibodies: their mechanisms of action and the pathological findings they induce in toxicity studies.

J Toxicol Pathol. 2015 Jul;28(3):133-9. doi: 10.1293/tox.2015-0031. Epub 2015 Jun 15.

PubMed ID
26441475 [ View in PubMed
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Abstract

Antibodies can swiftly provide therapeutics to target disease-related molecules discovered in genomic research. Antibody engineering techniques have been actively developed and these technological innovations have intensified the development of therapeutic antibodies. From the mid-1990's, a series of therapeutic antibodies were launched that are now being used in clinic. The disease areas that therapeutic antibodies can target have subsequently expanded, and antibodies are currently utilized as pharmaceuticals for cancer, inflammatory disease, organ transplantation, cardiovascular disease, infection, respiratory disease, ophthalmologic disease, and so on. This paper briefly describes the modes of action of therapeutic antibodies. Several non-clinical study results of the pathological changes induced by therapeutic antibodies are also presented to aid the future assessment of the toxic potential of an antibody developed as a therapeutic.

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