Role of zinc in hemostasis: a review.
Article Details
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Tubek S, Grzanka P, Tubek I
Role of zinc in hemostasis: a review.
Biol Trace Elem Res. 2008 Jan;121(1):1-8. doi: 10.1007/s12011-007-8038-y. Epub 2007 Oct 30.
- PubMed ID
- 17968515 [ View in PubMed]
- Abstract
Zinc is a multi-functional element that is found in almost 300 enzymes where it performs catalytic, co-catalytic, and/or structural functions. In 1982, Gordon et al. (Am J Clin Ntr 35:849-857, 1982) found that a low zinc diet caused poor platelet aggregation and increased bleeding tendency in adult males. This fact drew interest to the role of zinc in blood clotting. It has been shown that hyperzincemia predisposes to increased coagulability, and hypozincemia to poor platelet aggregation and increased bleeding time. The blood clotting disturbances can be regressed by appropriate zinc intake management. Considering the importance of zinc as an essential element, its participation in regulation of the equilibrium between pro- and anti-thrombotic factors originating in platelets and endothelium prompted further investigations.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Zinc chloride Coagulation factor XI Protein Humans UnknownActivatorDetails Zinc chloride Histidine-rich glycoprotein Protein Humans UnknownCofactorDetails Zinc sulfate, unspecified form Coagulation factor XI Protein Humans UnknownActivatorDetails Zinc sulfate, unspecified form Histidine-rich glycoprotein Protein Humans UnknownCofactorDetails