Organic nitrates: update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction.
Article Details
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Munzel T, Steven S, Daiber A
Organic nitrates: update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction.
Vascul Pharmacol. 2014 Dec;63(3):105-13. doi: 10.1016/j.vph.2014.09.002. Epub 2014 Oct 14.
- PubMed ID
- 25446162 [ View in PubMed]
- Abstract
Given acutely, organic nitrates, such as nitroglycerin (GTN), isosorbide mono- and dinitrates (ISMN, ISDN), and pentaerythrityl tetranitrate (PETN), have potent vasodilator and anti-ischemic effects in patients with acute coronary syndromes, acute and chronic congestive heart failure and arterial hypertension. During long-term treatment, however, side effects such as nitrate tolerance and endothelial dysfunction occur, and therapeutic efficacy of these drugs rapidly vanishes. Recent experimental and clinical studies have revealed that organic nitrates per se are not just nitric oxide (NO) donors, but rather a quite heterogeneous group of drugs considerably differing for mechanisms underlying vasodilation and the development of endothelial dysfunction and tolerance. Based on this, we propose that the term nitrate tolerance should be avoided and more specifically the terms of GTN, ISMN and ISDN tolerance should be used. The present review summarizes preclinical and clinical data concerning organic nitrates. Here we also emphasize the consequences of chronic nitrate therapy on the supersensitivity of the vasculature to vasoconstriction and on the increased autocrine expression of endothelin. We believe that these so far rather neglected and underestimated side effects of chronic therapy with at least GTN and ISMN are clinically important.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Isosorbide mononitrate Guanylate cyclase soluble subunit alpha-2 Protein Humans YesActivatorDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Isosorbide mononitrate Alcohol dehydrogenase class-3 Protein Humans NoSubstrateDetails Isosorbide mononitrate Glutathione S-transferase Mu 1 Protein Humans NoSubstrateDetails Isosorbide mononitrate Xanthine dehydrogenase/oxidase Protein Humans NoSubstrateDetails - Drug Reactions
Reaction Details - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAmyl NitriteAvanafil Avanafil may increase the hypotensive activities of Amyl Nitrite. Erythrityl tetranitrateAvanafil Avanafil may increase the hypotensive activities of Erythrityl tetranitrate. IsosorbideAvanafil Avanafil may increase the hypotensive activities of Isosorbide. Isosorbide dinitrateAvanafil Avanafil may increase the hypotensive activities of Isosorbide dinitrate. NitroglycerinAvanafil Avanafil may increase the hypotensive activities of Nitroglycerin.