Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues.

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Takayanagi I, Konno F, Ishii C, Takemasa T, Yanagida Y, Shimizu M, Mori H, Sugane H

Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues.

Gen Pharmacol. 1984;15(3):239-41.

PubMed ID

6329897 [ View in PubMed

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Abstract

Tizanidine behaved as the partial agonist on the alpha 1-adrenoceptor in high doses (10(-6) -10(-4)M) and as the alpha 2-adrenoceptor agonist in low doses (3 X 10(-9) - 10(-6)M). Tizanidine is about one-third as potent as clonidine in alpha 2-agonistic effect

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Tizanidine	Alpha-1 adrenergic receptors (Protein Group)	Protein group	Humans	Unknown	Agonist	Details