Reinforcing effect of pseudoephedrine isomers and the mechanism of action.
Article Details
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Wee S, Ordway GA, Woolverton WL
Reinforcing effect of pseudoephedrine isomers and the mechanism of action.
Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25.
- PubMed ID
- 15189772 [ View in PubMed]
- Abstract
It has been proposed that ephedrine and its isomers may have abuse potential. When made available to rhesus monkeys (n = 4) for self-administration, +-pseudoephedrine functioned as a positive reinforcer in all monkeys, as did (-)-pseudoephedrine in two of three monkeys. Pseudoephedrine isomers were 10- to 33-fold less potent than cocaine. In in vitro binding in monkey brain tissue, both isomers had low affinity for dopamine and serotonin transporters by at least 200-fold relative to cocaine, but comparable affinity for norepinephrine transporters. +-Pseudoephedrine also blocked dopamine uptake in 293 hDAT cells with low potency relative to cocaine. When given in vivo +-pseudoephedrine significantly displaced radioligand binding to dopamine transporters with a potency comparable to that in self-administration. Therefore, pseudoephedrine isomers can function as reinforcers and the mechanism at dopamine transporters may underlie this effect. However, pseudoephedrine appears to be a weak reinforcer and may have relatively low abuse potential.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ephedra sinica root Sodium-dependent dopamine transporter Protein Humans YesNegative modulatorDetails Ephedra sinica root Sodium-dependent noradrenaline transporter Protein Humans YesNegative modulatorDetails Ephedra sinica root Sodium-dependent serotonin transporter Protein Humans YesNegative modulatorDetails Pseudoephedrine Sodium-dependent dopamine transporter Protein Humans YesInhibitorDetails Pseudoephedrine Sodium-dependent noradrenaline transporter Protein Humans YesInhibitorDetails Pseudoephedrine Sodium-dependent serotonin transporter Protein Humans YesInhibitorDetails - Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Pseudoephedrine Sodium-dependent dopamine transporter Protein Humans UnknownInhibitorDetails Pseudoephedrine Sodium-dependent noradrenaline transporter Protein Humans UnknownInhibitorDetails Pseudoephedrine Sodium-dependent serotonin transporter Protein Humans UnknownInhibitorDetails