Suramin: clinical uses and structure-activity relationships.

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McGeary RP, Bennett AJ, Tran QB, Cosgrove KL, Ross BP

Suramin: clinical uses and structure-activity relationships.

Mini Rev Med Chem. 2008 Nov;8(13):1384-94.

PubMed ID

18991754 [ View in PubMed

]

Abstract

Suramin is a polysulfonated polyaromatic symmetrical urea. It is currently used to treat African river blindness and African sleeping sickness. Suramin has also been extensively trialed recently to treat a number of other diseases, including many cancers. Here, we examine its modes of action and discuss its structure-activity relationships.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Suramin	Follicle-stimulating hormone receptor	Protein	Humans	Yes	Antagonist	Details