Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.

Article Details

Citation

Copy to clipboard

Taldone T, Zito SW, Talele TT

Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):479-84. Epub 2007 Dec 3.

PubMed ID

18068977 [ View in PubMed

]

Abstract

Dipeptidyl peptidase-IV (DPP-IV) is an enzyme responsible for the inactivation of the glucoregulatory incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). In this report, we show that the hypolipidemic agent atorvastatin is a competitive inhibitor of porcine DPP-IV in vitro, with K(i)=57.8+/-2.3 microM. These results may have implications in the development of novel DPP-IV inhibitors based on the use of atorvastatin as a lead compound for the treatment of type 2 diabetes.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Atorvastatin	Dipeptidyl peptidase 4	Protein	Humans	Unknown	Inhibitor	Details