Alvimopan.
Article Details
- CitationCopy to clipboard
Neary P, Delaney CP
Alvimopan.
Expert Opin Investig Drugs. 2005 Apr;14(4):479-88.
- PubMed ID
- 15882122 [ View in PubMed]
- Abstract
Alvimopan is a synthetic peripherally restricted mu-receptor opioid antagonist. Alvimopan has a greater affinity for the mu-receptor than the kappa- or sigma-opioid receptors (Ki = 0.77 nM). The polarity of the molecule limits gastrointestinal absorption and central nervous system penetration. It has limited systemic bioavailability and higher affinity for the mu-opioid receptor than naloxone (Ki = 3.7 nM). Completed Phase III trials suggest efficacy in accelerating the recovery of gastrointestinal function after abdominal surgery. Adverse events with all doses have been similar to placebo groups. Further efficacy in alleviating opioid-induced bowel dysfunction in patients with chronic opioid usage has also been demonstrated. This evidence-based review assesses this new drug and discusses its potential role in clinical practice.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Alvimopan Delta-type opioid receptor Protein Humans UnknownAntagonistDetails Alvimopan Kappa-type opioid receptor Protein Humans UnknownAntagonistDetails Alvimopan Mu-type opioid receptor Protein Humans YesAntagonistDetails