Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate.

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Telimaa S, Apter D, Reinila M, Ronnberg L, Kauppila A

Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate.

Eur J Obstet Gynecol Reprod Biol. 1990 Jul-Aug;36(1-2):97-105.

PubMed ID

2142109 [ View in PubMed

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Abstract

The hormonal and biochemical effects of danazol (600 mg a day) and high-dose medroxyprogesterone acetate (MPA; 100 mg a day) were studied in a placebo-controlled, 6-month trial. Serum gonadotrophins and prolactin levels did not change during danazol and MPA treatments, whereas oestradiol and progesterone levels decreased significantly in relation to placebo without any difference between danazol and MPA. Both drugs significantly suppressed the sex hormone-binding globulin level (SHBG), and consequently, the free-androgen index (serum total testosterone nmol/l per SHBG nmol/l x 100) as compared with placebo, the effect of danazol being significantly stronger than that of MPA. Danazol, but not MPA, significantly increased serum aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and haemoglobin levels, and also thrombocyte counts, whereas MPA, but not danazol, increased the serum concentration of albumin in relation to placebo. Serum total bilirubin, conjugated bilirubin, gamma-glutamyl transferase, creatinine, alkaline phosphatase, sodium and potassium levels and leucocyte counts remained unchanged during both treatments. Danazol and high-dose MPA did not differ from each other in their ovarian and anterior pituitary effects, while the increase in androgenic activity induced by danazol was greater than that achieved with MPA. Danazol also had more biochemical effects than MPA. It interfered with the functions of the liver and the production of thrombocytes and haemoglobin, whereas MPA affected only albumin synthesis/release.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Danazol	Sex hormone-binding globulin	Protein	Humans	No	Antagonist	Details

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Danazol	Approved	Estradiol	decreased	Danazol decreases the level of Estradiol in the blood
Medroxyprogesterone acetate	Approved Investigational	Estradiol	decreased	Medroxyprogesterone acetate decreases the level of Estradiol in the blood
Medroxyprogesterone acetate	Approved Investigational	Progesterone	decreased	Medroxyprogesterone acetate decreases the level of Progesterone in the blood
Danazol	Approved	Progesterone	decreased	Danazol decreases the level of Progesterone in the blood